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management differential hematology symptoms workup antinxp2 arteritis chronic dermatology dermatomyositis erythematosus gca giantcell hemeonc hemophagocytic hlh leukemia lupus lymphocytic lymphohistiocytosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... autoimmune disease ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Physical Exam/Signs ... Hepatomegaly • Skin ... Diagnosis: • ... Scoring system:
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... signs/sx of inflammation ... required due to skip ... them, but urgent rheumatology ... GCA #Temporal #Signs
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Lacrimal swelling • Skin ... Central nervous system ... amyloidosis, PAH Skin ... Sjogrens #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... disease • Non-autoimmune ... rheumatologic diseases ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... purpura: Strong sign ... CRP GCA (Giant Cell ... #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... three days #AntiNXP2DM ... #diagnosis #management ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... Malignancies ▪ Autoimmune ... Presentation • Common Signs ... Infections, malignancy, autoimmune ... #Management #Hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system
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