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differential management syndrome classification dermatology symptoms systemic antinxp2 behcet clinical cryoglobulinemia cryoglobulins dermatomyositis disease erythematosus lupus manifestations myelodysplastic oncology scleroderma
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... polymorphism • Satellite ... Autoimmune manifestations ... leukocytoclastic vasculitis ... #differential #diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... ): • Limited cutaneous ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... aphthous ulcers, cutaneous ... purpura: strong sign ... of cutaneous leukocytoclastic ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... Labs/Diagnosis: ... Henoch-Schönlein purpura) • Cutaneous ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... purpura: Strong sign ... of cutaneous leukocytoclastic ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... ) • Cutaneous Lesions ... response to local skin ... #management #signs ... #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... disease • Non-autoimmune ... rheumatologic diseases ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Lacrimal swelling • Skin ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Sjogrens #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
in the neck Cutaneous ... chest (in a V-sign ... shoulders (in a shawl sign ... #diagnosis #management ... #rheumatology #
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