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diagnosis differential hematology table algorithm chronic cll cold disorders eosinophil eosinophilia gap globulin inflammatory leukemia lymphocytic myopathies myopathy myositis oncology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... organ-specific signs ... symptoms (eg, skin ... Differential #diagnosis #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... trigger - Direct skin ... 50% of patients Skin ... Urticaria #diagnosis #rheumatology ... #comparison #table
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... differential #diagnosis #comparison ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... Leukemia #diagnosis #workup ... #oncology #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gammopathy, and skin ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... differential #diagnosis #hematology
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