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diagnosis disease differential stills syndrome treatment adultonset symptoms vasculitis activation autoimmune behcet classification gca giantcell hematology macrophage mas myopathy myositis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
myocarditis, coronary arteritis ... SLE, Reactive arthritis ... Ocular melanoma • Arthritis ... SLE, Reactive Arthritis ... Recurrent and chronic arthritis-Azathioprine
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... maculopapular rash, arthritis ... low ferritin, arthritis ... #rheumatology # ... diagnosis #management
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... refractory disease Arthritis ... refractory disease Skin ... Syndrome #Treatment #management ... #pharmacology #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Fever, Arthralgia/arthritis ... , Skin rash ± odynophagia ... Disease #diagnosis #management ... #treatment #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
early evening • Arthritis ... Arthralgias or arthritis ... maculopapular skin ... Stills #disease #AOSD ... #management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... ) Giant cell arteritis ... versus Temporal Arteritis ... classic temporal arteritis ... #GiantCell #arteritis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... (sJIA) • Adult-onset ... juvenile idiopathic arthritis ... erythematosus [SLE], AOSD ... Syndrome #Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... GCA (Giant Cell Arteritis ... mucositis • Rash, arthritis ... and often causes arthritis ... Glomerulonephritis, arthritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and often causes arthritis ... Glomerulonephritis, arthritis ... mucositis - Rash, arthritis ... VASCULITIS: • Behçet ... purpura: strong sign
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... cancer-associated adult ... papules and Gottron sign ... ) • Shawl sign ... • Nonerosive arthritis
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