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diagnosis disease syndrome treatment adultonset differential symptoms vasculitis activation adult behcets classification fungal gca giantcell hematology infections infectiousdiseases macrophage mas
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... maculopapular rash, arthritis ... low ferritin, arthritis ... #rheumatology #diagnosis ... #management #treatment
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
myocarditis, coronary arteritis ... SLE, Reactive arthritis ... Ocular melanoma • Arthritis ... SLE, Reactive Arthritis ... Recurrent and chronic arthritis-Azathioprine
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Fever, Arthralgia/arthritis ... , Skin rash ± odynophagia ... Disease #diagnosis #management ... #treatment #rheumatology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... refractory disease Arthritis ... refractory disease Skin ... Syndrome #Treatment #management ... #pharmacology #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
early evening • Arthritis ... Arthralgias or arthritis ... maculopapular skin ... #disease #AOSD ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... • Adult-onset Still ... juvenile idiopathic arthritis ... erythematosus [SLE], AOSD ... Syndrome #Diagnosis #Management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... ) Giant cell arteritis ... versus Temporal Arteritis ... classic temporal arteritis ... #GiantCell #arteritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... GCA (Giant Cell Arteritis ... mucositis • Rash, arthritis ... and often causes arthritis ... Glomerulonephritis, arthritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and often causes arthritis ... Glomerulonephritis, arthritis ... mucositis - Rash, arthritis ... VASCULITIS: • Behçet ... purpura: strong sign
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... osteomyelitis or skin ... Meningitis, septic arthritis ... Mouth, throat, skin ... Fungal #Diagnosis #Management
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