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rheumatology algorithm anemia causes alopecia arterial cold cryofibrinogenemia cutaneous embolism extravascular focal glomerular hairloss hemolysis intravascular lesions monoclonal nephrology nephrotic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... thrombocytopenic purpura ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... DIC/TTP/HUS - Hemolytic ... Diagnosis #hematology ... #nonpalpable #dermatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Diagnosis: • hemolytic ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Leukocytoclastic Vasculitis Secondary ... Petechiae, Palpable purpura ... Vasculitis: • Behcet Disease ... • Cogan syndrome ... #dermatology #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Testosterone - Coumadin skin ... • Nephrotic Syndrome ... other causes of purpura ... #hematology #differential
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
and Focal) Differential ... Diagnosis Algorithm ... • Loose anagen syndrome ... to Skin Disease ... HairLoss #Alopecia #dermatology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
glomerulonephritis; HUS = hemolytic-uremic ... syndrome; aHUS ... glomerulonephritis; TTP = thrombotic ... nose (epistaxis), skin ... loss, causing secondary
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
necrosis) - Thrombosis ... (Thrombotic vasculopathy ... necrosis • Purpura ... Antiphospholipid syndrome ... hematology
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
- Differential ... Diagnosis Framework ... SAPHO syndrome ( ... Secondary syphilis ... #Diagnosis #Dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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