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diagnosis algorithm blood product reactions rheumatology skin activation apml differentiation erythematous joint lesions macrophage mas nikolsky nonpalpable oncology pain petechiae
Fever and Rash - Differential Diagnosis Framework • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... gonorrhea, Rickettsial diseases ... Erythema Multiforme, DRESS ... #Rash #Differential ... #Diagnosis #dermatology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
in vasculitic diseases ... with fever/toxicity ... rash, the diagnosis ... #Diagnosis #Dermatology ... #Purpuric #Rash
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH Vesiculobullous rashes provoke significant angst in many physicians (Figure 5, page
and a fever may ... , purpura fulminans ... hand-foot-and-mouth disease ... localized lesions and fever ... #Diagnosis #Dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... • Rheumatic fever ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... #skin #rashes #differential
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
includes Kawasaki disease ... erythematous rash ... #Diagnosis #Dermatology ... Algorithm #Nikolsky #Febrile ... #Fever #Differential
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Systemic Symptoms (DRESS ... extensive skin rash ... Fever >38.5 2. ... Resolution > 15 days Differentials ... #Syndrome #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
easy bruising to purpura ... (Petechial or purpuric ... rash) • Heart, ... #Diagnosis #Management ... #Hematology #Rheumatology
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Skin Lesions - Differential ... Generalized itchy rash ... Pustules + Fever ... pustulosis • Febrile ... #Diagnosis #Dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... Rare: DAH, acute febrile ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... maculopapular rash ... Causes purpura & ... Transfusion #diagnosis #management ... #hematology #reactions
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