ShamControlled pathophysiology complications hematology differential purpura syndrome rash management disease dress fever dermatology febrile oncology

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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition:
• Severe adverse drug reaction, characterized by

Systemic Symptoms (DRESS ... extensive skin rash ... Fever >38.5 2. ... Resolution > 15 days Differentials ... #Syndrome #dermatology

Differentiation Syndrome in APML
Epidemiology:
• Incidence: common in APL (2-48% depending on the study)
• Triggers:

ATRA treatment Pathophysiology ... Rare: DAH, acute febrile ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology

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