19 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... and Anticoagulant ... AntiCoagulation #Cascade #Anticoagulants ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... , CF, IBD) • Anticoagulant ... EricsMedicalLectures/ #Coagulation ... comparison #diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... DIC, TTP/HUS • Anticoagulants ... Differential #Diagnosis #hematology ... #rheumatology #
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology ... anticoagulation #anticoagulant
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
consider withholding anticoagulant ... decision to continue anticoagulant ... VTE and bleeding complications ... DOAC, direct oral anticoagulant ... Anticoagulation #Management #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... is simultaneous coagulation ... Reduction of pro/anticoagulants ... treatment #management #hematology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... of disease and complications ... SickleCell #Disease #Pathophysiology ... #Complications ... #Hematology #Sequelae
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... intravascular coagulation ... deficiency • Anticoagulants ... deficiency • Anticoagulant ... Differential #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
heparin - Other anticoagulants ... Congenital intrinsic coagulation ... intravascular coagulation ... #differential #hematology ... #coagulation