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differential management algorithm causes diuresis diuretics excretion hematology leukostasis lysis medications pharmacology potassium table tls tumor workup
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... Family history of hypokalemia ... • Unexplained hypokalemia ... #Syndrome #diagnosis ... #Hypokalemia
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Before evaluating hypokalemia ... in evaluating hypokalemia ... , Gitelman syndrome ... @krithicism #Hypokalemia
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... or induced) #Hypokalemia ... #nephrology
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Blood Work: - Hypokalemia ... Hypomagnesemia - Metabolic Alkalosis ... #Syndrome #Diagnosis ... #Workup #nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
fever - ACS, AKI ... , acute limb ischemia ... , Elevated Cr, Low ... hydration - Hyperkalemia ... #TLS #diagnosis
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Metabolic alkalosis ... • Diagnosis of ... Hyponatremia • Hypercalcemia ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology
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