10 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... syndrome - Mutation ... • Potassium • Magnesium ... #Gitelman #Syndrome ... #diagnosis #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Syndrome, Gitelman ... Syndrome Volume ... GRA, Cushing's syndrome ... , Liddle syndrome
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Mg wasting syndromes ... - Gitelman ... syndrome - ... - Hungry bones syndrome ... #Workup #hypomg
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... - Urinary Chloride ... use, Bartter syndrome ... , Gitelman syndrome ... #Urinary #Chloride
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
suggests extra-renal ... ↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... syndrome, Gitelman ... syndrome -
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Severe Cushing syndrome ... Congenital AME syndrome ... syndrome (defective ... calcium) alkali syndrome
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypokalemia - Hypomagnesemia ... - Metabolic Alkalosis ... #Syndrome #Diagnosis ... #Workup #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Syndrome, Gitelman ... Syndrome Euvolemic ... GRA, Cushing's syndrome ... , Liddle syndrome
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... and nephrotic syndrome ... and nephrotic syndrome ... disease • Liddle syndrome ... #Diuresis #Nephrology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
, including a diuretic ... and metabolic alkalosis ... Hypercalcemia, Cushing's syndrome ... White-coat syndrome ... Guillain-Barre Syndrome