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differential injury abnormal chemistry drug druginduced enzymes gastroenterology hepatitis idiosyncratic induced interpretation management plasmacytoma rvalue solitary transaminitis workup
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #differential #Diagnosis ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... disorder (e.g. ascites ... #Injury #Diagnosis ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... • Iatrogenic: DILI ... #differential #diagnosis ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... intestines, White blood cells ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... Areas of diagnostic ... Abnormal USS may well ... #LFTs #Abnormal ... #Algorithm #Hepatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
appearance Favored Sites ... common - GI tract, liver ... Diagnosis? ... #Plasmacytoma #Oncology ... #Hematology
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