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diagnosis differential management injury lfts transaminitis ascites aclf aflp alcoholic bilirubin chemistry chronic cirrhosis conjugated diffuse direct drug druginduced elevated
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
or symptoms of liver ... Drug #induced #Liver ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Drug-Induced liver ... #Causes #Differential ... #Hepatology #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Chronic Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... Differential #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Differential #Diagnosis #causes ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... , Acute biliary ... Differential #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... of Acute Liver ... • Iatrogenic: DILI ... #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Infectious • Hepatitis ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... Diagnosis: Viral Hepatitis ... #Pregnancy #hepatology
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