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hepatology liver differential injury gastroenterology lfts transaminitis aclf acute chemistry drug druginduced failure function hbv hepatitisb idiosyncratic induced interpretation rvalue
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Liver Injury (DILI ... ) Viral Hepatitis ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
- Differential Diagnosis ... • NAFLD • Cirrhosis ... • Chronic Viral ... (>1000): • DILI ... #hepatology #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
) - Stepwise Diagnosis ... Algorithm DILI ... e.g. ascites), Chronic ... hepatitis fibrosis ... #Algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... #differential #Diagnosis ... #algorithm #gastroenterology ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Management Algorithm ... viremia or have cirrhosis ... Chronic Hepatitis ... #Algorithm #Diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... > 2 • NASH, Chronic ... : < 1 • Cirrhosis ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
> 2 • NASH, Chronic ... : < 1 • Cirrhosis ... injury: > 3 • Chronic ... liver #chemistry #diagnosis ... #differential #Hepatology
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