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diagnosis hepatology liver differential gastroenterology injury transaminitis aclf acute chemistry drug failure function hbv hepatitisb idiosyncratic induced interpretation rvalue tests
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... • NAFLD • Cirrhosis ... • Chronic Viral ... Hepatitis Moderate ... (>1000): • DILI
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Liver Injury (DILI ... ) Viral Hepatitis ... #Hepatology #gastroenterology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Algorithm • ... viremia or have cirrhosis ... Chronic Hepatitis ... #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... > 2 • NASH, Chronic ... : < 1 • Cirrhosis ... injury: > 3 • Chronic ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... > 2 • NASH, Chronic ... : < 1 • Cirrhosis ... injury: > 3 • Chronic ... #hepatology
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