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diagnosis hepatology differential liver lfts injury transaminitis aclf acute aflp alcoholic chemistry common cvid diffuse druginduced failure fatigue fatty function
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Alcohol-Associated Hepatitis ... Liver Injury (DILI ... ) Viral Hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... • Chronic Viral ... Hepatitis Moderate ... • Acute Viral Hepatitis ... (>1000): • DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... hepatitis fibrosis ... • Autoimmune hepatitis ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #HepatitisB #HBV
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... heart failure (chronic ... #Differential #Hepatology ... #Cirrhosis #Causes
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 Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Infectious • Hepatitis ... • Alcoholic Hepatitis ... • Autoimmune Hepatitis ... • Drug Induced Hepatitis ... #Causes #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... Autoimmune: Autoimmune hepatitis ... • Iatrogenic: DILI ... viral hepatitis ... liver #injury #hepatitis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Differential Diagnosis Algorithm ... Neoplastic / Hematologic ... Epstein-Barr Virus • Hepatitis ... #causes
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Tuberculosis • Hepatitis ... Age > 50 • Chronic ... #Causes #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... #Causes
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