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Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #HepatitisB #HBV
Hepatitis B Management in Cancer

DOI: 10.1200/JCO.20.01757

#HepatitisB #HBV #HepBV #Management #Cancer #oncology #hepatology #algorithm
Hepatitis B Management ... JCO.20.01757 #HepatitisB ... #HBV #HepBV #Management ... Cancer #oncology #hepatology ... #algorithm
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... hepatitis C virus ... infectiousdisease #hepatology ... #HepC #HepatitisC ... #Management #Pharmacology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Alcohol-Associated Hepatitis ... (DILI) Viral Hepatitis ... #Acute #Chronic
Hepatitis B Phases and Treatment
Phase 1 - HBeAg+ Chronic Infection
Phase 2 - HBeAg+ Chronic Hepatitis
Phase 3
Hepatitis B Phases ... Hepatitis Phase ... Hepatitis Phase ... Burak @kwburak #HepatitisB ... #Treatment #Management
Hepatitis B Disease Progression Timeline
 • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... develop cirrhosis ... of developing cirrhosis ... #HepatitisB #Disease ... Timeline #Prognosis #hepatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... or fibrosis • Cirrhosis ... liver failure #HepatitisB ... #Indications #management ... #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
- Acute Viral Hepatitis ... , Toxic Hepatitis ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... hepatitis, Skeletal
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... e.g. ascites), Chronic ... hepatitis fibrosis ... • Autoimmune hepatitis ... #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Differential Diagnosis Chronic ... liver disease (cirrhosis ... or chronic hepatitis ... failure - 3-5% Cirrhosis ... Differential #Diagnosis #hepatology