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diagnosis differential dermatology oncology pruritus alopecia focal generalized hairloss systemic abdominal allergy anemia aplastic chronic ckd diffuse disorders eosinophil gastroenterology
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Diagnosis Algorithm ... Primary Eosinophilia ... Leukemia • MPN ... Secondary Eosinophilia ... GI, lung, skin),
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... • Screen for secondary ... causes of eosinophilia ... symptoms (eg, skin ... Differential #diagnosis #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Causes == Primary ... • Lymphoma • Leukemia ... #secondary #systemic ... #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• (Peripheral eosinophilia ... + distinctive primary ... bone marrow and secondary ... CLL -> Invade Skin ... #Hematology #Oncology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... • Lymphoma • Leukemia ... #Pruritus #secondary ... #causes
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... decalvans - Secondary ... to Skin Disease ... Congenital hair shaft ... #causes
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
Abdominal Pain Causes ... Back pain • Skin ... infarction • Lymphoma/Leukemia ... hernia • Rib fracture ... pseudoobstruction • Eosinophilic
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Abnormalities in primary ... or secondary hemostasis ... cryoglobulins • Skin ... #Causes #dermatology
Focal / Localized Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required - Infectious
Differential Diagnosis Algorithm ... decalvans - Secondary ... to Skin Disease ... Congenital hair shaft ... #causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... - Hepatitis, eosinophilic ... virus (EBV) • Leukemia ... #diagnosis #management
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