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diagnosis differential alp dermatology generalized phosphatase systemic workup anemia biliary cholangitis cirrhosis cryofibrinogenemia elevation hyophosphatasia leukemia low normocytic oncology polycythemia
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... - Fatigue - Pruritis ... - Drugs - Primary ... #hepatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Causes == Primary ... Hyperthyroidism CBC ... #primary #secondary ... #causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... asymptomatic • Pruritus ... Examination: • Skin ... Labs: • Alkaline ... diagnosis #workup #hepatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... Hyperthyroidism CBC ... #secondary #systemic ... #causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... #Causes #Hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• recurrent fractures ... pain • loss of secondary ... Phosphatase: • Other causes ... • Elevation of urinary ... Hyophosphatasia #hepatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Primary (essential ... • Painful or pruritic ... cryoglobulins • Negative causes ... Warfarin-induced skin ... #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... else is driving RBC ... causes: Many of ... #workup #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
sweats, bleeding • Pruritis ... + distinctive primary ... bone marrow and secondary ... CLL -> Invade Skin ... #Leukemia #Hematology
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