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diagnosis differential oncology alopecia causes chronic conditions dermatology diffuse extrarticular focal gap globulin hairloss joint leukemia lymphocytic mds monoclonal myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... plaques, nodules, ulcers ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
neuritis - Giant cell ... Scrotal or vulvar ulcers ... ENT • Oral ulcers ... Scleroderma Thickened skin ... differential #diagnosis #rheumatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... • Loose anagen syndrome ... - Secondary to Skin ... Congenital hair shaft ... Differential #Diagnosis #Algorithm
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can Feature ... Lymphoma (HCV) • CLL ... Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... characteristic feature ... Workup: • Complete ... #diagnosis #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
CRP GCA (Giant Cell ... livedo reticularis, ulcers ... purpura, nodules or ulcers ... genital aphthous ulcers ... Differential #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
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