12 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
#Binding #KBinders ... Kayexelate #Comparison #Table ... #Pharmacology # ... Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... #Hyperkalemia # ... treatment #pharmacology ... #table #comparison ... #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
action on the nephron ... Metolazone) 5) Potassium-sparing ... triamterene) #nephron ... #diuretics #pharmacology ... #nephrology #medications
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison ... #binders
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... • Consider K+ binder ... and ECG changes ... blocks, QRS axis shift ... #potassium #high
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
Phosphate binders ... since they are not able ... restricted due to hypercalcemia ... Only* #CKD #Nephrology ... #Dose #Dosing #Pharmacology
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Used Phosphate Binders ... #Phosphate #Binders ... #Table #Comparison ... #Pharmacology # ... Nephrology
Medications for the Treatment of Hyperkalemia
The goals of acute treatment are to prevent potentially life-threatening cardiac
disturbances, shift ... potassium into ... eliminate excess potassium ... , changes on ECG ... , and Table 3 summarizes
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Shift of extracellular ... fluid/Lactated ringers ... Monitor potassium ... per day until stable ... causes #treatment #nephrology
KDIGO Treatment algorithm for management of acute hyperkalemia in the emergency department
 • Place on cardiac
management of acute hyperkalemia ... monitor 12-lead ECG ... • Consider K+ binder ... algorithm #treatment #potassium ... #high #nephrology