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differential causes high nephrology medications rhabdomyolysis treatment adverseeffects agitation antipsychotic bb betablocker classification criticalcare delirium druginduced encephalopathy icu infusion neurology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Beta Blocker Side Effects / Toxicity Cardiac Side Effects: • Sinus bradycardia, AV block, Heart failure exacerbation,
blocker withdrawal syndrome ... Facilitation of hyperkalemia ... BetaBlocker #BB #SideEffects ... #pharmacology # ... diagnosis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... reactions Common Drugs ... Intracellular Shift ... - Tumor lysis syndrome ... #causes #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... - Tumor lysis syndrome
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
and Management ... Drugs (Statins), ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Framework and Management ... - Toxins - Drugs ... Shift of extracellular ... Monitor potassium
Neurological Side Effects of Antipsychotic Drugs Acute dystonia - Spasm of muscles of tongue, face, neck, back
Antiparkinsonian agents are diagnostic ... tremor ("rabbit syndrome ... #Medications #SideEffects ... #pharmacology # ... management
Propofol-Related Infusion Syndrome (PRIS) Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
(PRIS) Diagnosis ... Hypertriglyceridemia • Hyperkalemia ... #PRIS #Diagnosis ... #Management #Pharmacology ... #Toxicity #Toxicology
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
extracellular shift ... Drug-associated: ... antiphospholipid syndrome ... #Differential #Diagnosis ... #High #Potassium
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Blood transfusion, Hypercalcemia ... factor PRES Diagnosis ... abnormality, Medication/Drug ... toxicity, Metabolic ... #diagnosis #management
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