18 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Hypokalemia Differential ... tubular acidosis • Gitelman's ... syndrome • Bartter's ... syndrome Extrarenal ... Transcellular shift
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... - Refeeding Syndrome ... #Hypokalemia ... potassium #low #pathophysiology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... excess, Liddle syndrome ... , Gitelman syndrome ... #hypokalemia
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
BRASH Syndrome ... ) BRASH Treatment ... • Aggressive treatment ... DrEricStrong #BRASH #Syndrome ... diagnosis #management #pathophysiology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... Rhabdomyolysis Treatment ... nephrology #management #pathophysiology ... #Hypokalemia
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
of Tumor Lysis Syndrome ... (TLS) and Treatment ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome ... diagnosis #management #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... #Tumor #Lysis #Syndrome ... #TLS #oncology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Dialysis for severe hyperkalemia
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
Gitelman Syndrome ... - Management Treatment ... In persistent hypokalemia ... #Syndrome #Management ... #Treatment #nephrology