Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric acid ≥ 8.0 mg/dL • Potassium ≥ 6.0 mEq/dL • Phosphorus ≥ 4.6 mg/dL • Calcium ≤ 7.0 mg/dL Clinical TLS: • AKI (defined as creatinine > 1.5x the upper limit of normal for patient age and sex) • Cardiac arrhythmia • Seizure, tetany, or other symptomatic hypocalcemia Treatment of TLS: • Hypovolemia - Intravenous fluids • Renal failure - Dialvsis • Hyperuricemia - Allopurinol, Rasburicase • Hyperphosphatemia - Aluminum hydroxide • Hyperkalemia - Standard treatment • Hypocalcemia - Calcium gluconate #TumorLysis #Syndrome #TLS #diagnosis #management #oncology
