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diagnosis hyperkalemia causes treatment nephrology high algorithm medications pathophysiology comparison table diabetes digoxin dm2 dosing druginduced endocrinology hematology hypokalemia inhibitors
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... Benyzlpenicillin, blood ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
minutes) Decrease potassium ... • IV Fluids Shift ... potassium intracellularly ... peaks 1-2h) • Blood ... #Hyperkalemia #management
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... 15 g QD • Side Effects ... 8.4 g • Side Effects ... of aspiration #Potassium ... #medications #pharmacology
Sulfonylureas - Pharmacology Summary Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... Mechanisms of Action: Binds ... ATP-sensitive potassium ... CKD Common Side Effects ... Sulfonylureas #Pharmacology
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... binder that can ... Most common side effect ... #Binder #KBinder ... #Hyperkalemia #Pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... - Protective effects ... transcellular shift ... NS #comparison #pharmacology ... #effects
Clozapine blood monitoring for side effects of agranulocytosis and granulocytopenia #management #psychiatry #antipsychotics #pharmacology #medications #dosing #clozapine
Clozapine blood ... monitoring for side effects ... granulocytopenia #management ... antipsychotics #pharmacology
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... • Consider K+ binder ... Dialysis Serum potassium ... blocks, QRS axis shift ... #hyperkalemia #potassium
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... for Management ... cyclosilicate #Potassium ... #Binders #Management ... Hyperkalemia #treatment #pharmacology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... effective arterial blood ... Non-reabsorbable anion effect ... #differential #
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