19 results
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #Hyperkalemia # ... treatment #pharmacology ... #table #comparison
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... : Treatment of Hyperkalemia ... oral suspension DOSING ... #Binder #KBinder ... Pharmacology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... Benyzlpenicillin, blood ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
• Consider K+ binder ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management ... #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... Clenching of fist during ... phlebotomy High ... Crush injury • Blood ... Intracellular Shift
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Diagnosis Framework ... Clenching of fist during ... phlebotomy High ... Crush injury • Blood ... Intracellular Shift
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... effective arterial blood ... #urine #potassium ... differential #algorithm #diagnosis
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... densa receives high ... #pharmacology #
Causes of Hyperkalemia - Differential Diagnosis Framework
 • Cellular Shift:
   - Exercise
- Differential Diagnosis ... Framework • Cellular Shift ... : Blood draw error ... #Causes #potassium ... #high