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management nephrology causes differential high comparison summary agonists algorithm binder binding cholinergic gitelman hypokalemia kbinder medications pathophysiology patiromer syndrome veltassa
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison ... #binders
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... Management of Hyperkalemia ... #Hyperkalemia # ... treatment #pharmacology ... #table #comparison
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... : Treatment of Hyperkalemia ... oral suspension DOSING ... #Binder #KBinder ... Pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Differential Diagnosis ... Shift of extracellular ... fluid/Lactated ringers ... Monitor potassium ... per day until stable
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Differential Diagnosis ... Shift of extracellular ... Monitor potassium ... per day until stable ... Dialysis for severe hyperkalemia
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... • Consider K+ binder ... blocks, QRS axis shift ... #diagnosis #management ... #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... Clenching of fist during ... Intracellular Shift ... lysis syndrome - Rhabdomyolysis ... #causes #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... Clenching of fist during ... • Recent IV potassium ... Intracellular Shift ... lysis syndrome - Rhabdomyolysis
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
retention • Binds ... Produces miosis during ... Edrophonium • Used for diagnosis ... Cholinergic #Agonists #Pharmacology ... #Table #Summary
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
hypokalemic salt-losing ... (renal potassium ... • Seizures • Rhabdomyolysis ... Treatment - ... Gitelman #Syndrome #diagnosis
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