Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds preferentially at muscarinic receptors Carbachol • Produces miosis during ocular surgery • Used topically to reduce intraocular pressure in open-angle or narrow-angle glaucoma, particularly in patients who have become tolerant to pllocarplne Pilocarpine • Reduces intraocular pressure in open-angle and narrow-angle glaucoma • Binds preferentially at muscarinic receptors Uncharged, tertiary amine that can penetrate the CNS Physostigmine • Increases intestinal and bladder motility • Reverses CNS and cardiac effects of tricyclic antidepressants • Reverses CNS effects of atropine • Uncharged, tertiary amine that can penetrate the CNS Neostigmine • Prevents postoperative abdominal distention and urinary retention • Used In treatment of myasthenia gravis • Used as an antidote for competitive neuromuscular blockers • Has intermediate duration of action (0.5 to 2 hrs) Edrophonium • Used for diagnosis of myasthenia gravis • Used as an antidote for competitive neuromuscular blockers • Has short duration of action (10 to 20 min) Rivastigmine, galantamine, donepezil • Used as first-line treatments for Alzheimer's disease, though confers modest benefit • Have not been shown to reduce healthcare costs or delay institutionalization • Can be used with memantine (N-methyl-D-aspartate antagonist) with moderate to severe disease Echothiophate • Used in treatment of open-angle glaucoma • Has long duration of action (100 hours) Acetylcholine • Used to produce miosis in ophthalmic surgery #Cholinergic #Agonists #Pharmacology #Table #Summary
