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differential hepatology injury liver causes lfts rheumatology aih dili druginduced erythematosus gap globulin hepatocellular liverenzymes lupus management myopathy myositis protein
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
- Differential Diagnosis ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #Differential #Diagnosis ... #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... Autoimmune hepatitis ... extrahepatic source - Tests ... #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Algorithm Severe ... • Ischemia • Autoimmune ... • Cholestatic disease ... Bile Ducts • PSC ... • Alcoholic hepatitis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver test ... • Infections: Hepatitis ... Other: NAFLD, Autoimmune ... HELLP, Celiac disease ... #hepatology #algorithm
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... reported (eg AIH-PBC ... #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... Alcohol-related liver disease ... dechallenge • Acute ... steatosis • Autoimmune ... #Algorithm #hepatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Differential Diagnosis ... • Non-autoimmune ... deficiencies • Autoimmune ... Noninfectious hepatitis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... myopathies Diagnostic ... Tests: • Measure ... : • PBC, autoimmune ... hepatitis, Psoriasis
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