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diagnosis differential dermatology dermatomyositis erythematosus lupus symptoms syndrome systemic vasculitis algorithm antimda5 antimda5dm antinxp2 antinxp2dm autoimmune behcet classification color ddxof
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... Polyneuropathy, Cranial nerve ... erythematosus #signs
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
High-risk Features ... Ill-appearing, vital sign ... sulfa-drug - Skin ... #Dermatology #Rash ... Targetoid #Algorithm #Differential
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... ulcerations • Skin ... 50% of cases • Skin
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... glomerular ischemia - Skin ... purpura: strong sign ... Small Vessels: Skin
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... syndrome Clinical Features ... Seizures • Strokes Skin
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
response to local skin ... retinal damage) • Skin ... test (this is a skin ... #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... purpura: Strong sign ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... overlaps with RA, SLE ... myelopathy, cranial nerve ... amyloidosis, PAH Skin ... : • Dry skin (xerosis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... chest (in a V-sign ... shoulders (in a shawl sign ... ulcerations • Skin ... ulcerations • Auricular skin
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Alterations: - Sensory features ... • Bilateral signs ... brain and/or optic nerve ... Myelitis #diagnosis #management ... #neurology #differential
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