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diagnosis differential hematology oncology leukemia vasculitis allergy amyloidosis causes classification dermatology erythematosus gap globulin immunology lupus lymphocytic mds myelodysplasia myelodysplastic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
(Chronic Myeloid ... develop leukostasis syndrome ... • Tumor lysis syndrome ... -> Invade Skin: ... #Leukemia #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... inflammatory disorders ... Myelodysplastic syndrome ... myeloid leukemia ... (CML) - Dr.
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Summary Group of disorders ... : • Nephrotic syndrome ... Infiltration of muscles Skin ... waxy or thickened skin ... Tests: • Nerve
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Hepatomegaly • Skin ... lymphoproliferative disorders ... • Richter’s Syndrome ... #Chronic #Lymphocytic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... just beneath the skin ... Marrow Failure • Chronic ... Neutropenia • Platelet Disorders ... blood count with differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... Cryoglobulinemic Vasculitis - Skin ... glomerular ischemia - Skin ... Small Vessels: Skin
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... with Lupus: • Chronic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... commonly affects the skin ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
an exaggerated skin ... Skin trauma → Erythematous ... • Chronic myeloid ... What is the skin ... #dermatology #skin
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... gammopathy, and skin ... changes (POEMS syndrome ... Connective tissue disorders ... Gap #ProteinGap #differential
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