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diagnosis differential hematology chronic conditions erythematosus extrarticular gap globulin joint leukemia lupus lymphocytic mds monoclonal myelodysplasia myelodysplastic pain paraproteinemias protein
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... lymphoproliferative disorders ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... et diutinum Neurologic ... thrombosis+Pulm HTN+skin ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... just beneath the skin ... Neutropenia • Platelet Disorders ... blood count with differential ... #oncology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
neuritis - Giant cell ... - SLE Neurologic ... Scleroderma Thickened skin ... #joint #pain #differential ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... commonly affects the skin ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Erythematosus #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... gammopathy, and skin ... changes (POEMS syndrome ... Connective tissue disorders ... Gap #ProteinGap #differential
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