30 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
New Potassium-Binding ... Agents - Dr. ... Kayexelate #Comparison #Table ... Pharmacology #Patiromer #HyperKalemia ... #Nephrology #Agents
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia.
 - At
Hyperkalemia shortens ... repolarization; changes ... #Diagnosis #Hyperkalemia ... #EKG #ECG #Changes ... #Progression #Table
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat ... • Mechanism: Exchanges ... aspiration #Potassium #Binding ... #pharmacology #table
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... Treatment Algorithm ... ECG changes, weakness ... changes? ... removal of offending agent
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
, Hypokalemia, Erectile ... potential Ca2+ channel ... failure Ca2+ channel ... Pgp-dependent drugs (e.g ... contraindications #table
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
S - Shock H - Hyperkalemia ... Typical ECG ... proportion to other findings ... of hyperkalemia ... • If on a Ca2+ channel
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... Algorithm • IV ... potassium and ECG ... changes • 5.5 ... , asystole #hyperkalemia
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
the parenteral agents ... (e.g. heparin, ... conformational changes ... conformational change ... inhibits factor Xa by binding
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Hyporeflexia: • Hypercalcemia ... polyneuropathy (e.g ... Hyperreflexia: • Delayed finding ... stroke, Delayed finding ... differential #diagnosis #table
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
require phosphate binding ... agents since they ... are not able to ... restricted due to hypercalcemia