Compelling and Possible Contraindications to Antihypertensive Drugs Diuretics (thiazides) - Gout - Metabolic syndrome, Glucose intolerance, Pregnancy, Hypercalcemia, Hypokalemia, Erectile dysfunction Mineralocorticoid receptor antagonists (MRA) - Hyperkalemia, Serum creatinine >2.5 mg/dl„ in men, >2.0 mg/dL in women) - Situations associated with higher risk of hyperkalemia (ACEI, ARB, diabetes) ACE inhibitors - Pregnancy, Angioneurotic edema, Hyperkalemia, Bilateral renal artery stenosis - Women with child-bearing potential Angiotensin receptor blockers - Pregnancy, Hyperkalemia, Bilateral renal artery stenosis - Women with child-bearing potential Ca2+ channel blockers (dihydropyridines) - Tachycardia/arrhythmia, Heart failure Ca2+ channel blockers (verapamil, diltiazem) - AV block (grade 2-3), Severe LV dysfunction, Heart failure - Co-medication with CYP3A4- or Pgp-dependent drugs (e.g. statins, digoxin) Beta Blockers - Asthma, AV block (grade 2-3) - Metabolic syndrome, Glucose intolerance, Athletes and physically active patients, Chronic obstructive lung disease, Psoriasis, Depression Alpha Blockers - Heart failure Central sympatholytic drugs - Depression, AV block (grade 2-3) - Erectile dysfunction, Xerostomia #antihypertensive #medications #contraindications #table #bloodpressure #prescribing
