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diagnosis hematology oncology algorithm aplastic causes common cvid differential generalized hypogammaglobulinemia immunodeficiency immunology lupus lymphocytic mds myelodysplasia myelodysplastic primary pruritus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... -> Invade Skin: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Cancer affecting ... • Richter’s Syndrome ... syndrome • Smoldering ... #CLL #Chronic ... workup #oncology #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
) • Atopic dermatitis ... == Blood Glucose ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... just beneath the skin ... Marrow Failure • Chronic ... Cell Leukemia ... #diagnosis #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome ... dermatosis (Sweets Syndrome ... classical Sweet syndrome ... - Schnitzler’s syndrome ... Treatment: - Systemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome ... with Lupus: • Chronic
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... ) • Systemic granulomatous ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... From Blood Cancer ... Myelodysplastic syndromes ... acute myeloid leukemia ... #algorithm #hematology
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