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diagnosis differential management oncology leukemia algorithm chronic cll disorders erythematosus gap globulin hodgkins infections lupus lymphocytic lymphoma lymphoproliferative mycobacteria myopathy
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #Hematology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... ingestion • B symptoms ... -95% of cases) Classification ... #diagnosis #classification ... #hematology #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Lacrimal swelling • Skin ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... #Rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... with no early symptoms ... Hepatomegaly • Skin ... • Richter’s Syndrome ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Disease Classification ... rheumatologic diseases ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... CLL -> Invade Skin ... #Leukemia #Hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... disease, alcohol, cancer ... Hematologic malignancy ... differential #diagnosis #infectiousdiseases
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
Malignancies, including lymphoma ... mesothelioma, etc - Autoimmune ... Pathophysiology ... and the systemic symptoms ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... • Anti-TIF1 (cancer-associated ... stomach, colon, and lymphoma ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... changes (POEMS syndrome ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... differential #diagnosis #hematology
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