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diagnosis hematology differential oncology algorithm chronic cll disorders erythematosus gap lupus lymphocytic lymphoproliferative nonhodgkin protein proteingap sle systemic workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... with no early symptoms ... Hepatomegaly • Skin ... increase in gamma globulins ... • Sezary syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... CLL -> Invade Skin ... #Leukemia #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... Treated Like Acute Leukemias ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... gammopathy, and skin ... changes (POEMS syndrome ... ovarian tumors, lung cancers ... : Lymphoma, Leukemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Disease Classification ... Induced Lupus: • Symptoms ... and leukemia • ... Lung cancer •
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