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neurology diagnosis causes management ocular ophthalmology acetylcholinereceptor achr algorithm clinical diplopia eyelid intravenousimmunoglobulin ivig musclespecificreceptortyrosinekinase myastheniagravis myastheniccrisis neuromuscular nif ocularmyasthenia
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... Ocular- 50%: Ptosis ... chewing, loss of smile ... life-threatening Differential ... immunologic assay - MuSK
Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
Gravis (MG): • ... Patients with MuSK-MG ... because of bulbar weakness ... ocularmyasthenia #ptosis ... muscle-specificreceptortyrosinekinase #AChR #MuSK
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
non-localized EOM weakness ... and bilateral ptosis ... Myasthenia gravis ... tumor, and always ask ... #clinical #video
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 Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Sensory Changes - Differential ... • Cardio-pulmonary ... Oculomotor • Myasthenia ... Gravis • Lambert-Eaton ... Myasthenic Syndrome
Ptosis - Differential Diagnosis Framework Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Ptosis - Differential ... Myasthenia gravis ... and weakness of ... gravis • Botulinum ... gravis • Ocular
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... anti—muscle-specific kinase (MuSK ... antibodies - MuSK-positive ... or respiratory weakness ... #Gravis #diagnosis
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate ... #Causes #differential
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Non-neuromuscular disorder (Cardiac ... Postsynaptic: Myasthenia ... Gravis - Lack ... #Differential #
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