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diagnosis neurology causes gravis acetylcholinereceptor achr algorithm clinical diplopia endocrinology eyelid hyperthyroidism intravenousimmunoglobulin ivig management musclespecificreceptortyrosinekinase musk myastheniagravis myastheniccrisis neuromuscular
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... chewing, loss of smile ... Limb- proximal weakness ... life-threatening Differential ... immunologic assay - MuSK
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Sensory Changes - Differential ... • Cardio-pulmonary ... Oculomotor • Myasthenia ... Gravis • Lambert-Eaton ... Myasthenic Syndrome
Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
with worsening of Myasthenia ... Gravis (MG): • ... higher risk of myasthenic ... because of bulbar weakness ... #VC #NIF #PEF #
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM weakness ... Myasthenia gravis ... tumor, and always ask ... #clinical #video
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 Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate ... #Causes #differential
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Non-neuromuscular disorder (Cardiac ... Postsynaptic: Myasthenia ... Gravis - Lack ... #Differential #
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
irregularities • Weakness ... diffuse goiter (Graves ... Graves' disease ... Cardiac arrhythmia ... causes #diagnosis #differential
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