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management differential neurology algorithm chronic cll disorders eosinophil eosinophilia gravis hemeonc hemophagocytic hlh leukemia leukostasis lymphocytic lymphohistiocytosis lysis myasthenia myopathy
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
have fever - ACS ... WBC >100k, + lab signs ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... myasthenia Diagnosis ... Serologic and EMG ... test - Cogan sign ... - Peek sign
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy Presentation:
Bell's Palsy - Diagnosis ... ophthalmoplegia), systemic signs ... and Workup: • ... No additional workup ... /NCS (rare): assist
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... phenomenon CLL Diagnosis ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... necrotizing myopathy • Autoimmune ... dystrophies Work ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... Malignancies ▪ Autoimmune ... Presentation • Common Signs ... Infections, malignancy, autoimmune ... #Management #Hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... myopathies Diagnostic ... Aldolase levels • EMG ... papules and Gottron sign ... ) • Shawl sign
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