6 results
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
: CHF, valves, COPD ... chemo), EtOH, Rhabdomyolysis ... , Critical illness ... • Neuro: UMN (stroke ... Diagnosis #causes #neurology
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... findings: - Weakness ... dysfunction - Flaccid ... syndromes #lesions #differential ... #diagnosis #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Impairment: • Acute stroke ... of the spinal cord ... Lyme myositis • Rhabdomyolysis ... Diagnosis #neurology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Differential Diagnosis ... Heat injury, Heat stroke ... Dermatomyositis Clinical ... Muscle pain - Weakness ... - Dark urine
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
form part of the differential ... muscle atrophy, weakness ... very different clinical ... of the foot is stroked ... hyporeflexia, flaccid
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
tubule (DCT) Clinical ... Fatigue • Muscle weakness ... Hypocalciuria (spot urine ... ratio 0.5%) Differential ... • Seizures • Rhabdomyolysis