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diagnosis treatment disease adultonset aosd hemophagocytic hlh lymphohistiocytosis adult bacilliformis bartonella erythematosus lupus macrophage mas onset oroya sle summary syndrome
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... #AdultOnset #Stills ... Disease #diagnosis #management ... #treatment #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... #AdultOnset #Stills ... Disease #AOSD #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Adult-onset Still ... MAS #Macrophage #Activation ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... • Clinical: fever ... +, Adult-onset Still ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... and cytokine storm ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... Inflammation: high fever ... , malaise, chills ... coinfection, toxo reactivation ... #diagnosis #management
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... - Fever spikes ... #Adult #onset #Stills ... AOSD #diagnosis #rheumatology ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... arthritis, adult-onset Still ... to: Arthritis, Fever ... Chronic B-cell activation ... Erythematosus #Diagnosis #Rheumatology
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