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diagnosis treatment disease adultonset hematology hemophagocytic hlh lymphohistiocytosis activation adult cardiology endocarditis fungal infections infectiousdiseases macrophage mas mycoses onset summary
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... : high fever, CRP ... #rheumatology #diagnosis ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... #AdultOnset #Stills ... Disease #diagnosis #management ... #treatment #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... #Adult #onset #Stills ... #disease #AOSD ... #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... - Nonremitting fever ... erythematosus [SLE], AOSD ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine storm ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... +, Adult-onset Still ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Generalized: • Chills ... night sweats, fever ... Paradoxical emboli via ASD ... Persistent bacteremia/fevers ... Endocarditis #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... , cough, chills, ... pulmonary symptoms • Rheumatologic ... • Isolated fever ... Fungal #Diagnosis #Management
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