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diagnosis causes dyspnea aa algorithm amiodarone arterial chronic gradient hypoxemia hypoxia induced management toxicity toxicology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Dyspnea - Differential ... Parenchyma: ILD • Alveoli ... Hepatopulmonary syndrome ... - Obesity - Flail ... Pain #dyspnea #sob
Approach to the A-a Gradient A-a gradient = PAO2 - PaO2 A-a gradient = [FiO2 x (Patm -
Weakness, Loss of Chest ... Wall Elasticity (flail ... chest) • Low ... , Interstitial Lung ... Hypoxia #hypoxemia #differential
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm Pericardial • Effusion • Cardiac Tamponade* • Constriction Myocardial •
Stable Angina • Acute ... Coronary Syndrome ... Thickening/Masses Chest ... Alveoli • Pneumonia ... Chronic #Dyspnea #SOB
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
toxicity (e.g., acute ... respiratory distress ... syndrome) is rare ... Pleuritic chest ... macrophages in alveolar
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