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diagnosis management differential anemia dermatology ana anca antibodies antibody antineutrophil antinuclear aplastic classification diseases disorders dress elevatedmcv eosinophil eosinophils hes
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Diagnosis and Treatment ... Algorithm Matthew ... #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Parasites Drugs: - DRESS ... Hypereosinophilic Syndrome ... Differential #Diagnosis #Causes ... #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... for secondary causes ... (common causes ... glucocorticoid treatment ... Differential #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Myelodysplastic Syndromes ... Liver Function Tests ... Liver Function Tests ... #Causes #Hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Reaction with Eosinophilia ... Edema in 70% of cases ... Eosinophilia 4 ... disease: symptomatic treatment ... #Syndrome #dermatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
seen in 30—70% of cases ... • Sjögren syndrome ... ANCA+ 60% • Eosinophilic ... Polyangiitis (Churg-Strauss ... antibodies #diagnosis #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... - Hepatitis, eosinophilic ... aplastic anemia Treatment ... Anemia #oncology #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... Rule out other causes ... and lower jaw Treatment ... blockers had the best ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... tract, and often causes ... • Cogan Syndrome ... retinopathy Lab Tests ... differential #diagnosis #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
hearing loss, nausea ... diseases 30% of cases ... Diagnosis: • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology
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