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diagnosis rheumatology differential disease monoclonal oncology agglutinin anemia antinxp2 antinxp2dm behcet cold common cvid dermatomyositis gammopathy hemolytic hemophagocytic hlh hypogammaglobulinemia
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Differential Diagnosis Neurologic-Centered ... nemaline myopathy Cutaneous-centered ... capillary leak syndrome ... Differential #Diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can ... gangrenosum • Cutaneous ... et diutinum Neurologic ... Autoantibodies: • WAIHA • CAD ... Paraproteinemias #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... presentation) • Cutaneous ... agglutination After CAD ... hemolytic #anemia #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... vasculitis) • Cutaneous ... skin injury) • Neurologic ... (Clinical Dx). ... #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Diagnosis: • A clinical ... TNF blockers had ... diagnosis #management ... #Dermatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
-> 40 years • Can ... to 8 years Clinical ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... signs and symptoms can ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
activity • Via cutaneous ... three weeks Clinical ... Complications: • Cutaneous ... MPOX #Diagnosis #Management ... #Dermatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
5-6th Decades (can ... salivary ducts Clinical ... skin (xerosis) • Cutaneous ... Nephrogenic DI Hematologic ... Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
in the neck Cutaneous ... auricular papules Clinical ... Dermatomyositis #diagnosis #management ... #rheumatology # ... dermatology
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