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differential dermatology algorithm systemic generalized oncology pruritus rheumatology common cryofibrinogenemia hypogammaglobulinemia immunodeficiency immunology leukemia management mds myelodysplasia myelodysplastic naildisorders neutropenia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... #Causes #hematology ... #secondary
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... leakage of RBC's secondary ... - Hemolytic anemia ... Kasabach-Merritt syndrome ... #hematology #rheumatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... • Nephrotic syndrome ... #Diagnosis #Algorithm ... #causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Systemic and Primary Causes ... renal failure/uremia ... Myelodisplastic syndrome ... Pruritus #primary #secondary
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... DDX: Rule Out Secondary ... Causes • Anemia ... #diagnosis #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... Chediak-Higashi syndrome ... drug reactions - Secondary ... Megaloblastic anemia-rare ... #causes #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
disease 2019 (COVID ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
renal failure/uremia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #generalized #dermatology ... #Algorithm #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
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