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differential management rheumatology algorithm dermatology generalized pruritus allergy cerebritis classification cns common cryofibrinogenemia cryoglobulinemia cryoglobulins cvid effusions erythematosus hemeonc hemophagocytic
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... - Differential Diagnosis ... Infection - Systemic ... #Effusions #causes ... #differential #diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... and Primary Causes ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... • Nephrotic syndrome ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... autoantibodies that will cause ... permeability Diagnosis ... APS), Secondary
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
- Differential Diagnosis ... into a 4-pass system ... pass = Dangerous secondary ... cell activation syndrome ... #hematology #allergy
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... Type III Often Secondary ... Labs/Diagnosis:
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
processes: • Systemic ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... hemolytic anemia) • Systemic ... DDX - Other causes ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... Diagnosis: • Dry ... Hypocomplementemia • Can cause ... Central nervous system ... Nephrogenic DI Hematologic
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
- Differential Diagnosis ... Myelodisplastic syndrome ... #Pruritus #secondary ... #systemic #generalized ... #causes
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