181 results
Steroid Synthesis Pathway

Dr. Caoimhe Costigan @CaoimheCostigan

#Steroid #Synthesis #pathophysiology #algorithm #endocrinology
Steroid Synthesis ... CaoimheCostigan #Steroid #Synthesis ... pathophysiology #algorithm ... #endocrinology
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Metabolism Synthesis ... Pathophysiology #Functions #Liver ... #Hepatology #Synthesis
Steroid Synthesis Pathway

(OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
Steroid Synthesis ... CaoimheCostigan #Steroid #Synthesis ... pathophysiology #endocrinology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... salts augment synthesis ... ALP - Due to synthesis ... source - Tests of synthetic ... differential #diagnosis #algorithm
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... In liver, 80% of ... phosphatase: • Synthesis ... due to increased synthesis ... clearance - AP synthesis
Insulin and Glucagon Pathophysiology
Insulin: 
 • Glucose utilization (Glycolysis)
 • Glucose storage (Glycogenesis)
 • Fat synthesis
Glycogenesis) • Fat synthesis ... Lipogenesis) • Protein synthesis ... Actions: • Glucose synthesis ... Pathophysiology #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... expression/protein synthesis ... #FeedbackLoop #endocrinology
Calcium homeostasis is a process controlled by chiefly by hormones vitamin D and PTH. 
Vitamin D
circulation via synthesis ... processes in the liver ... Pathophysiology #Endocrinology
Vitamin D Metabolism
Fat-soluble vitamin
Sources: dermal synthesis and food (dairy products, fish)
Active form: calcitriol (1,25-OH Vitamin D)
Main
Sources: dermal synthesis ... VitaminD #Metabolism #endocrinology
Hirsutism & Virilization - Differential Diagnosis Algorithm
ADRENAL EXCESS
Ovarian
 • Polycystic Ovarian Syndrome
 • Hyperthecosis
 • Tumor
Adrenal
Differential Diagnosis Algorithm ... • Obesity • Liver ... Differential #Diagnosis #Algorithm ... #endocrinology