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The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Without treatment ... - Rash, pink ... and nephrotic syndrome ... to asymptomatic infection ... roots, causing a syndrome
Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 • Direct lesion contact during sex is responsible
Manifestations and Treatment ... • Direct lesion ... loss • Skin: Rash ... Albuminuria, nephrotic syndrome ... Treatment:
Natural History of Syphilis
Primary - 2-6 weeks after infection
 • Chancre, Regional lymphadenopathy
Early Latent ≤ 1
-6 weeks after infection ... ≤ 1 year after infection ... • Rash, Fever ... lymphadenopathy, Mucosal lesions ... > 1 year after infection
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
Infectious Joint ... • Secondary Syphilis ... Papules & Mucosal Lesions ... & Symmetrical Rash ... (Measles- like rash
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Ring-Enhancing Lesions ... Diagnosis- Compatible syndrome ... splenomegaly Other infections ... Infectious: ... Tuberculosis • Syphilis
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
Rash Secondary ... with or without treatment ... , but without treatment ... , the infection ... heaped, wart-like lesions—Condyloma
Approach to the Rash in a an oncology patient - MINT-C Mnemonic
M - Malignancy: Leukemia cutis,
Approach to the Rash ... , Viral infections ... Dermatoses: Sweet Syndrome ... Gangrenosum, NEH T - Treatment ... dermatoses #skin #Rash
Stages of Syphilis
Early Primary:
 • Painless chancre
 • Regional lymphadenopathy
Early Secondary:
 • Fever, malaise
 • Rash
Stages of Syphilis ... Fever, malaise • Rash ... first year of infection ... Gummatous • Nodular lesions ... BostonChiefs #Syphilis
CENTRAL FACIAL / NASAL LESIONS
Bacteria:
 • Leprosy (saddle nose deformity)
 • Tuberculosis (lupus vulgaris)l
 • Endemic
FACIAL / NASAL LESIONS ... Endemic treponemal infection ... • Congenital syphilis ... Trigeminal trophic syndrome ... Facial #Central #Lesions
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Viral: Measles, Infectious ... meningitis, Secondary syphilis ... , DRESS, Sweet syndrome ... SCVMCMed #Fever #Rash